ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases
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چکیده
منابع مشابه
Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.
Despite recent advances in the treatment of colon cancer, tumor resistance is a frequent cause of chemotherapy failure. To better elucidate the molecular mechanisms involved in resistance to irinotecan (and its active metabolite SN38), we established SN38-resistant clones derived from HCT-116 and SW48 cell lines. These clones show various levels (6- to 60-fold) of resistance to SN-38 and displa...
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BACKGROUND Colon cancer during pregnancy is a relatively rare occurrence. To date there has been sparse clinical evidence about the safety of chemotherapy in this setting because the available data derive only from single-institution case reports. METHODS Irinotecan and fluorouracil, as part of the FOLFIRI regimen, were administered to a 33-year-old pregnant woman at an estimated gestational ...
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Using seven monoclonal SN38-resistant subclones established from ME180 human cervical squamous cell carcinoma cells, we examined the demethylation effects of 5-aza-2'-deoxycytidine (5-aza-CdR) on the SN38-sensitivity of the cells as well as the expression of death-associated protein kinase (DAPK) in the SN38-resistant cells. The DAPK expression le...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2004
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.20032